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Epidemiology Journal Club | Parallel Evolution in Avian Influenza Viruses

Monday 12 October 202617:30 - 18:30
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UCL IOE, 20 Bedford Way, Room C3.15Not on our map yet
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๐Ÿ‘ฉโ€๐Ÿ”ฌ Speaker: Dr Marina Escalera-Zamudio ๐Ÿ“… Date: 12 October 2026 โฐ Time: 5:30 PM to 6:30 PM ๐Ÿ“ Location: C3.15, IOE - Bedford Way (20) ๐Ÿ“‘ Paper: Parallel evolution in the emergence of highly pathogenic avian influenza A viruses https://www.nature.com/articles/s41467-020-19364-x Why do some avian influenza lineages repeatedly evolve into highly pathogenic forms while others do not? This paper uses viral genomes, phylogenetics, statistical modelling and protein-structure evidence to identify mutations repeatedly associated with the independent emergence of highly pathogenic influenza lineages. Weโ€™ll be joined by Dr Marina Escalera-Zamudio , a UCL epidemiologist whose research uses genomic data and evolutionary modelling to understand and anticipate viral variation. The session will ask how confidently we can reconstruct evolutionary events from genomic data: does repeated mutation imply adaptation, how do we separate association from mechanism, and could evolutionary genomics ever help us predict which viral lineages are most likely to become dangerous? Themes: viral genomics ยท parallel evolution ยท phylogenetics ย ยท predicting pathogen emergence
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